ABCC1 promotes GSH-dependent iron transport and resistance to Fe(II) and Cu(II) chelators.

ABSTRACT: Therapy resistance is a major challenge in cancer treatment, with multidrug resistance (MDR) being a well-characterized phenomenon wherein cancer cells develop resistance not only to the administered drug but also to structurally diverse compounds. Metal chelators, including quinolines and thiosemicarbazones, have shown broad antitumor activity and potential in overcoming MDR by modulating metal metabolism. However, predicting whether chelators increase or decrease toxicity in MDR cells remains complex, especially as chelator-metal complexes may become substrates for ATP-binding cassette (ABC) transporters, leading to resistance or hypersensitivity. In this study, we developed cell lines with comparable expression levels of the three major MDR ABC transporters (ABCB1, ABCC1, and ABCG2). Ou

SUBMITTER: Gaal A 

PROVIDER: S-EPMC12686069 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature