Pharmacological therapies for type 2 diabetes: future approaches.

ABSTRACT: Despite the availability of at least nine differently acting classes of glucose-lowering agents, many people with type 2 diabetes do not achieve or maintain sufficiently tight glycaemic control to avoid the complications of chronic hyperglycaemia. This narrative review examines the prospects for future non-insulin agents and therapeutic approaches in early development that aim to improve glycaemic control in type 2 diabetes. Such therapies will ideally enhance glucose lowering through existing mechanisms or by targeting different aspects of disease pathophysiology. They will avoid overt hypoglycaemia and facilitate weight control and be convenient to use, have minimal adverse effects, provide benefits against common comorbidities and have a commendable overall safety profile. Particularly

SUBMITTER: Bailey CJ 

PROVIDER: S-EPMC12686082 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature