Progression of the estimated glomerular filtration rate in asphyxiated neonates undergoing therapeutic hypothermia during the first 10 days of life.

ABSTRACT:

Background

Serum creatinine (Scr) centile values were recently described in a cohort of 1136 (near)-term neonates that underwent therapeutic hypothermia (TH) because of moderate to severe hypoxic-ischemic encephalopathy. Recent methodological progress enables conversion of these Scr centiles to estimated glomerular filtration rate (eGFR) values.

Methods

Scr centiles in the TH dataset during the first 10 days of life were converted to eGFR values, using the Schwartz formula, with the Smeets k-value (0.31) and fixed body length (50 cm) to generate postnatal reference eGFR values, centiles, and an equation for median eGFRs. These findings were compared to published eGFR data in term controls.

Results

A polynomial function was estimated: eGFRmLmin∙1.73m2=9.1667+7.1173-0.3

SUBMITTER: Allegaert K 

PROVIDER: S-EPMC12686099 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature