Cross-linked Chitosan-Based Shell with Mirtazapine Lipid Polymer Hybrid Core as Integrated Spray-Dried Bionanocomposites for Boosted Brain-Directed Oral Delivery.

ABSTRACT: Brain-directed delivery can elaborate locally to treat various brain ailments like the globally prevalent depression. Fulfilling such a goal via oral delivery can be conceivable owing to its expedience of self-medication and non-invasiveness. In this context, the oral behavioral trend was customized via tripolyphosphate cross-linked chitosan-based shell with lipid polymer hybrid core (TPP:CS-LPH) enclosing the antidepressant drug, mirtazapine (MIR). LPH nanoparticles were made of the PLGA core and the newly investigated lipid shell of lecithin and the pegylated lipid, Tefose 1500. Considering industrial scalability and applicability, spray drying was performed with thorough characterization. The impact of a cross-linked chitosan-based shell with LPH core on the in vivo pharmacokinetic beha

SUBMITTER: Elbehairy DM 

PROVIDER: S-EPMC12686112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature