Nano-Mediated Fluorescence Switching for Epidermal Growth Factor Receptor Detection.

ABSTRACT: Identification of the epidermal growth factor receptor (EGFR) in biological specimens is essential for cancer diagnostics, drug development and therapeutic monitoring. However, real-time techniques for accurate EGFR expression monitoring are currently limited. In this study, we report the development of a novel nano detector (Cy3-Apt_EGFR@BPNSs) with the capabilities of quenching and recovery to enable visual EGFR expression analysis. Cy3-Apt_EGFR is a Cy3-labelled single-stranded RNA (ssRNA) that exhibits specific binding to EGFR. Black phosphorus nanosheets (BPNSs) possess the ability to adsorb Cy3-Apt_EGFR via van der Waals forces, quenching its fluorescence when combined. The detection of EGFR receptors on cancer cell surfaces prompts the release of Cy3-Ap

SUBMITTER: Fu X 

PROVIDER: S-EPMC12686125 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature