Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1-Mediated Trophoblast Differentiation in the Placenta.

ABSTRACT: The appropriate allocation of nutrients between the mother and the fetus during mammalian pregnancy primarily depends on a healthy placenta. Fetal growth restriction (FGR) is frequently associated with inadequate maternal nutrition supply and impaired placental function. The precise mechanisms linking maternal nutrient deficiency to compromised fetal and placental development remain largely elusive. In this study, we conducted an in-depth analysis by integrating single-cell/single-nucleus RNA sequencing data from human and mouse placentas along with transcriptomic data from FGR placenta, identifying the GAB1 (GRB2-associated binding protein 1) gene as a potential mediator of dysregulated maternal-fetal exchange, thereby affecting fetal growth. Using a mouse model, we demonstrated that food

SUBMITTER: Fan M 

PROVIDER: S-EPMC12686128 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature