NFATc1 activates the Ras/Raf/p38 MAPK pathway to promote the progression of lung adenocarcinoma.

ABSTRACT:

Background

The incidence rate and mortality rate of lung adenocarcinoma (LUAD) are in the forefront of malignant tumors in recent years. Due to its atypical early manifestations, many patients are diagnosed at advanced stages and miss the opportunity for timely intervention, resulting in a poor 5-year overall survival rate. Therefore, identifying specific targets in LUAD is essential for molecular precision therapy. This study integrates clinical and basic research to elucidate the diagnostic value and clinical significance of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) in LUAD.

Methods

Immunohistochemistry (IHC) and immunofluorescence (IF) were first employed to detect the protein expression and localization of NFATc1 in LUAD and adjacent tissues. Receiver op

SUBMITTER: Sun A 

PROVIDER: S-EPMC12686139 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature