PM2.5 promotes non-small cell lung cancer tumorigenesis by miR-21-5p targeting <i>PDE4DIP</i> accumulated.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Fine particulate matter (PM2.5) is associated with increased risk of lung cancer. microRNAs (miRNAs) play an important role in a variety of cancers, including NSCLC. In NSCLC, existing literature has revealed upregulation of miR-21-5p. Nonetheless, the molecular mechanism of miR-21-5p in NSCLC development after PM2.5 exposure is not clear. This study aimed to investigate the role of miR-21-5p in NSCLC development after PM2.5 exposure and to elucidate the underlying molecular mechanisms.

Methods

Expression of miR-21-5p, PDE4DIP, and SORBS2 was determined in NSCLC cell lines and tumor tissues. To measure proliferation, migration/invasion of NSCLC cells, 3-(4,

SUBMITTER: Lin YJ 

PROVIDER: S-EPMC12686157 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature