ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths globally. It poses a significant threat to human health with high incidence and mortality rates. Current treatments like surgery, chemotherapy, and radiation have limited efficacy and often encounter drug resistance, highlighting the need for new therapeutic targets and strategies. The aim of this study was to assess how ING5 regulates lncOIP5-AS1, miR-381-3p, and SEC24A, and exerts its tumor-suppressive effects.

Methods

We developed NSCLC cell lines that overexpressed ING5 and transfected them with a miR-381-3p inhibitor and short hairpin RNA (shRNA) targeting long non-coding RNA (lncRNA) OIP5-AS1. The impact of lncRNA OIP5-AS1 on NSCLC cell proliferation, tumorigenesis, and migration

SUBMITTER: Cui W 

PROVIDER: S-EPMC12686164 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature