Clinicopathological characteristics and long-term prognosis of duodenal signet ring cell carcinoma: a SEER-based analysis.

ABSTRACT:

Background

Signet ring cell carcinoma (SRCC) of the duodenum represents an exceedingly uncommon and highly aggressive variant of duodenal malignancy. Due to its scarcity, the clinicopathological features and long-term prognostic outcomes of duodenal SRCC remain poorly understood. The present study endeavors to analyze these aspects using data from the Surveillance, Epidemiology, and End Results (SEER) database.

Methods

Patients with duodenal SRCC and adenocarcinoma (AC) diagnosed from 2000 to 2021 were retrieved from the SEER database. Propensity score matching (PSM) approach was used to address confounding factors. The comparison of clinicopathological features was conducted utilizing Chi-squared tests. The evaluation of overall survival (OS) and cancer-specific survival (C

SUBMITTER: Ding J 

PROVIDER: S-EPMC12686181 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature