Uridine-cytidine kinase 2 as a novel potential prognostic and therapeutic biomarker in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most prevalent and lethal malignancies worldwide, with its high mortality rate attributed to late diagnosis, limited prognostic stratification tools, and a lack of targeted therapeutic options. This study aimed to explore the biological functions and molecular mechanism of uridine-cytidine kinase 2 (UCK2) in GC to identify powerful diagnostic, prognostic, and therapeutic biomarkers for GC.

Methods

We systematically analyzed the expression pattern of UCK2 across multiple datasets, including The Cancer Genome Atlas (TCGA) GC cohort, Gene Expression Omnibus (GEO) datasets, and a prospectively collected cohort of GC patients from Department of Gastric Surgery, Tianjin Medical University Cancer Institute and Hospital (Tianjin, China) (

SUBMITTER: Sun W 

PROVIDER: S-EPMC12686192 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature