Genetic insights into colorectal cancer pathogenesis: a multi-omics and immunity perspective.

ABSTRACT:

Background

Colorectal cancer (CRC) is a global health issue influenced by both genetic and environmental factors. Identifying key genes closely associated with CRC is crucial for understanding its pathological mechanisms and discovering therapeutic targets. This study aimed to integrate multi-omics datasets and Mendelian randomization (MR) approaches to identify CRC-related genes and to clarify their roles in tumor immunity and therapeutic potential.

Methods

This is a cross-sectional study. We utilized databases such as Gene Expression Omnibus (GEO), Finnish National Genome Project (FinnGen), expression Quantitative Trait Loci (eQTL), and The Cancer Genome Atlas (TCGA), and employed MR, summary-data-based MR (SMR), and gene expression analyses to screen genes related to CRC

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12686208 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature