A novel pyridazinone and thiophene compound IMB5043 activated apoptosis and autophagy in cisplatin-resistant non-small cell lung cancer cells.

ABSTRACT:

Background

Lung cancer is still one of the top three malignant tumors in the world at present and one of the cancers with the lowest survival rate. Cisplatin is one of the most commonly used chemotherapy drugs, but the development of drug resistance can lead to the death of patients who are ineffective to the treatment. IMB5043 is a pyridazinone and thiophene compound which is cytotoxic to cancer cells. This article aims to explore its effect on cisplatin-resistant lung cancer cells.

Methods

Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay was used to detect the cyto-toxicity of different concentrations of cisplatin and IMB5043 on non-small cell lung cancer (NSCLC) H460 cells and its cisplatin-resistant cell (H460/DDP). The effect of IMB5043 on cell migration and inva

SUBMITTER: Hou Y 

PROVIDER: S-EPMC12686209 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature