Neutrophil depletion dampens inflammation and enhances CD8⁺ T cell effect on tumor control but undermines anti-PD-1 therapy.

ABSTRACT:

Background

Lung cancer remains a leading cause of cancer-related mortality, with poor survival outcomes. Despite the widespread use of programmed cell death protein 1 (PD-1) blockade therapy, more than 70% of patients fail to benefit and might even develop adverse inflammatory responses. Clinical observations have shown that patients with high neutrophil levels experience worse outcomes following PD-1 blockade. However, the underlying mechanism remains elusive. This study aimed to investigate the impact of neutrophils on anti-PD-1 therapy in lung cancer.

Methods

Clinical cohort analysis revealed that peripheral neutrophil levels correlated with survival and metastasis in non-small cell lung cancer (NSCLC) patients treated with PD-1 blockade. In this study, we established a s

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12686212 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature