Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis of 4,929 Patients.

ABSTRACT: BackgroundCerebral venous thrombosis (CVT), a rare cause of stroke, primarily occurs in young individuals. The established treatment regimen involves anticoagulation with low molecular weight heparin (LMWH) and vitamin K antagonists (VKA). Although direct oral anticoagulants (DOACs) have emerged as a promising alternative, their efficacy and safety remain unclear. This meta-analysis compared the efficacy and safety of DOACs versus VKA in managing CVT.MethodsElectronic databases, including PubMed, Cochrane Library, and ScienceDirect, were searched from inception until April 2025. Risk ratios (RR) with a 95% Confidence interval (CI) were pooled under the random effects model in the Review Manager 5.4.1. Quality assessment was done through the Cochrane risk of bias (RoB 2.0) tool and the Newc

SUBMITTER: Waseem MH 

PROVIDER: S-EPMC12686367 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature