Mendelian Randomization Analyses Support Causal Relationships Between Psychiatric Disorders and Risk of Urinary Tract Infections.

ABSTRACT: Observational studies have identified a significant co-morbidity between urinary tract infections (UTIs) and psychiatric disorders, yet the causal relationship remains uncertain. We conducted a bidirectional Mendelian randomization (MR) analysis to evaluate the causal relationship between psychiatric disorders (schizophrenia [SC], bipolar disorder [BD], major depressive disorder [MDD], autism spectrum disorder [ASD], attention-deficit/hyperactivity disorder [ADHD], obsessive-compulsive disorder [OCD], anorexia nervosa [AN]) and UTIs using data from the Psychiatric Genomics Consortium and UK Biobank. To account for potential confounding factors and investigate the independent effects of multiple psychiatric disorders, we further employed multivariable Mendelian randomization (MVMR). Inverse

SUBMITTER: Ke M 

PROVIDER: S-EPMC12686375 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature