Combined RP-HILIC for suspect screening of persistent, mobile, and toxic substances in surface water: A case study.

ABSTRACT: Persistent, Mobile, and Toxic (PMT) and very Persistent and very Mobile (vPvM) substances pose a significant environmental threat due to their widespread distribution, persistence, and potential toxicity. While previous studies have used reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) to extend analyte coverage, this study uniquely integrates a dual-chromatographic approach with multi-sorbent solid phase etration (SPE) and machine-learning-based retention time indices to rigorously minimize false positives and enhance confidence in suspect screening of PMT/vPvM substances. Two independently optimized LC methods (RP and HILIC) were applied in parallel to the same SPE extract to identify potential chromatographic blind spots. We applied this robust framework to

SUBMITTER: Mottaghipisheh J 

PROVIDER: S-EPMC12686432 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature