Microbiota-host crosstalk: the role of short-term dietary restriction in neurological and metabolic dysregulation.

ABSTRACT: Excessive dieting (ED), a common weight-control strategy, often causes neurological and emotional disturbances, yet its gut-brain interaction mechanisms remain unclear. Employing a short-term dietary (SDR) adult male rabbit model, we found that SDR can induced cerebral cortex up-regulation of the immune-related genes (e.g., C1QC, SAA3) enriched in NF-kappa B signaling pathways, contrasted with down-regulation of sex hormone-related genes (e.g., PRLR, SPA17) implicated in metabolic homeostasis. Furthermore, dysregulated expression of metabolic genes (e.g., PPM1J, GALNT18) in the cecum of the SDR group interacted to impair the immune protection pathways related to intestinal mucosa. Then, SDR significantly increased the cecal Firmicutes/Bacteroidetes ratio (from 3.38 to 5.57) and reduced mic

SUBMITTER: Li Y 

PROVIDER: S-EPMC12686470 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature