RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc^.

ABSTRACT: Ferroptosis is a distinct form of programmed cell death that differs from other pathways. It is characterized by iron-dependent lipid peroxidation and results in morphologically lethal cellular damage. With advancing insight, triggering ferroptosis is a promising strategy for cancer therapy. RNA-binding proteins (RBPs) comprise a diverse group of molecules that regulate various RNA processes through interactions with transcripts. Research has highlighted the pivotal role of RBPs in controlling biological functions. Evidence indicates that RBPs play important roles in regulating ferroptosis. Heterogeneous nuclear ribonucleoprotein U (HnRNPU) is a well-known RBP involved in RNA splicing, messenger RNA stability and chromatin organization. Elevated HnRNPU expression has been implicated in can

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12686487 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature