Ferritinophagy-related prognostic genes UBE2Q1, NEDD4L, and TCP11L2 for prognosis prediction in sepsis.

ABSTRACT: Sepsis remains a critical global health threat characterized by high mortality and complex immune-metabolic dysregulation. This study identifies ferritinophagy-related prognostic genes (FRGs) that are causally linked to sepsis outcomes using a multi-omics approach integrating bulk and single-cell transcriptomics with Mendelian randomization. Among 1047 candidate genes, UBE2Q1, NEDD4L, and TCP11L2 were selected to build a risk model that effectively stratified sepsis patients and predicted mortality. Functional enrichment analysis revealed associations with oxidative phosphorylation, ribosome function, and Parkinson's disease pathways. Immune infiltration analysis identified increased γδ T and NK cell levels in high-risk patients, with significant correlations to prognostic genes. Single-ce

SUBMITTER: Xiong W 

PROVIDER: S-EPMC12686514 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature