Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates With Aging-Associated Airway Remodeling.

ABSTRACT: Aging generates a variety of phenotypes in the lungs with increased alveolar airspaces or emphysema, decreased surface area, and increased disease susceptibility. Senescence, oxidative stress, and mitochondrial dysfunction are known contributory factors. However, the underlying mechanisms promoting unhealthy aging remain unclear. Adenine nucleotide Translocase 1 (ANT1), a mitochondrial ADP/ATP transporter, is important for mitochondrial metabolism. Loss of ANT1 has been implicated in the development of pulmonary fibrosis, a disease characterized by accelerated lung aging, through mitochondrial dysfunction and senescence. To determine the role of ANT1 in normal lung aging, we analyzed aged human lung data from the Human Lung Cell Atlas and evaluated the ANT1-related mechanism in an aged gen

SUBMITTER: Jha R 

PROVIDER: S-EPMC12686547 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature