Reasons for Healthcare Use Before Onset of Multiple Sclerosis: A Nationwide Matched Cohort Study in Sweden.

ABSTRACT:

Background

Evidence suggests signs and symptoms may emerge years before the clinical onset of multiple sclerosis (MS). We investigated secondary healthcare use and medication dispensations before MS onset.

Methods

Using linked administrative data, we analyzed a neurologist-diagnosed MS clinical cohort and an algorithm-defined administrative cohort in Sweden (2001-2019). People with MS (PwMS) were matched to up to five non-MS comparators by sex, birth year, residency location, and residency duration before the index date (clinical: symptom onset; administrative: first MS/demyelinating diagnosis code). Annual outpatient visits and hospitalizations by diagnosis codes across 19 years pre-index, and dispensed medications by anatomical and therapeutic classifications across 14 yea

SUBMITTER: Manouchehrinia A 

PROVIDER: S-EPMC12686564 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature