Age-Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV-Infected Macaques.

ABSTRACT: With the advancement of combination antiretroviral therapy (ART), over 50% of people with HIV (PWH) in the United States are now over the age of 50. A hallmark of the aging immune system is a progressive dysfunction of both the innate and adaptive immune responses, often characterized by clonal expansion of memory T cells. However, the impact of age-related immune dysfunction on HIV/SIV reservoir dynamics remains understudied. We hypothesized that age-associated clonal expansion of memory T cells contributes to the increase of the HIV reservoirs in older PWH (OPWH). In this retrospective study, we utilized archived peripheral blood mononuclear cells (PBMCs) from young and older PWH with suppressed plasma viremia for at least 5 years and quantified both intact and total HIV proviral DNA fro

SUBMITTER: Acharya A 

PROVIDER: S-EPMC12686580 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature