CirRFKB: A knowledgebase of circadian-related risk factors for cancer pathogenesis and personalized medicine.

ABSTRACT: Circadian rhythms regulate numerous physiological and biochemical processes in humans, and their disruption is linked to elevated cancer risk and progression. Although substantial research has elucidated interactions between circadian mechanisms and cancer pathways, these findings remain fragmented and poorly integrated, impeding a holistic understanding. To address this gap, we developed the Circadian-Related Risk Factor Knowledgebase for Cancer (CirRFKB), a manually curated repository documenting validated associations between the circadian clock and cancer. CirRFKB curates data from 471 articles, encompassing 46 cancer types and 4052 records, categorizing risk factors into 1449 single factors and 340 combinations. Single factors were categorized into 681 genetic factors, 106 environment

SUBMITTER: Wang J 

PROVIDER: S-EPMC12686628 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature