The role of circulating metabolomics in linking metabolic dysfunction, inflammation, and risk of diverticulitis outcomes.

ABSTRACT:

Background

Obesity and chronic inflammation are associated with an elevated risk of diverticulitis. However, the underlying mechanisms, particularly the role of circulating metabolites are not well understood.

Methods

We derived metabolomic signatures of metabolic dysfunction (body mass index, waist circumference, C-peptide, and adiponectin) and inflammation (C-reactive protein, interleukin 6, and tumor necrosis factor receptor superfamily 1B). We then predicted metabolomic signatures among 7888 participants who were free of diverticulitis at blood collection in Nurses' Health Study (NHS), NHSII, and Health Professional Follow-up Study (HPFS) and evaluated their association with risk of diverticulitis incidence, recurrence, and surgery.

Findings

Metabolomic signatures

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12686631 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature