Low-calorie diet intervention ameliorates gut microbiota dysbiosis and metabolic changes in obese patients with type 2 diabetes under standard care.

ABSTRACT:

Background

Dietary interventions can modulate the gut bacteria community (microbiota) and offer a complementary strategy for improving metabolic control in type 2 diabetes (T2D). This pilot study evaluated clinical clinical outcomes and gut microbiota changes following a structured low-calorie diet (LCD) intervention in obese T2D individuals under standard care.

Methods

Twenty obese T2D patients were randomized into an intervention group (n = 15) (6-week 1000-1200 kcal/day of glycemic and metabolic control LCD), or a matched control group (n = 5). Clinical parameters and fecal microbiota profiles were assessed at baseline, week 6, and week 12.

Results

The intervention group showed clinical trends toward improved glycemic and metabolic parameters, including reductions

SUBMITTER: Umphonsathien M 

PROVIDER: S-EPMC12686632 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature