Nidogen 1-enriched extracellular vesicles promote liver metastasis by inducing EMT and activating stellate cells.

ABSTRACT: The liver is frequently affected by metastasis in colorectal cancer patients; however, the precise interaction between the liver microenvironment and metastatic colorectal cancer cells remains elusive. Our study revealed that NID1, present in extracellular vesicles (EVs) derived from metastatic colorectal cancer, plays a pivotal role in promoting colorectal cancer liver metastasis (CRLM). EV-NID1 facilitates epithelial-mesenchymal transition (EMT) in colorectal cancer cells by modulating EMT-associated genes. Moreover, EV-NID1 activates hepatic stellate cells (HSCs), which in turn stimulate neutrophil infiltration and induce the formation of neutrophil-trapping networks (NETs) within the hepatic metastatic microenvironment via interleukin-11 (IL-11) secretion. This process ultimately resha

SUBMITTER: Chen H 

PROVIDER: S-EPMC12686717 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature