Real-World Impact on Postoperative Vomiting by Changing Anesthesia Regimens in Children Undergoing Strabismus Surgery: An Interrupted Time Series Analysis.

ABSTRACT:

Background

Preventive measures for postoperative vomiting (POV) in pediatric strabismus surgery are essential. Previous experimental studies have shown the independent antiemetic effects of propofol-based total intravenous anesthesia (TIVA), dexamethasone (DEX), and ondansetron (OND). However, the real-world outcomes of POV following the combined use of DEX and OND with propofol/opioid TIVA remain unknown.

Aims

To evaluate the longitudinal incidence of POV across three phases of different anesthesia regimens.

Methods

This retrospective observational study was conducted at a single tertiary-care children's hospital in Japan, including children aged < 18 years who underwent strabismus surgery and had no major comorbidities. The primary outcome was either POV or the use

SUBMITTER: Kojima T 

PROVIDER: S-EPMC12686758 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature