Effects of Intraoperative Ventilation Strategies on Ventilation Inhomogeneity and Inflammatory Response in Pediatric Cardiac Surgery-A Randomized Pilot Study.

ABSTRACT:

Background

Respiratory arrest during cardiopulmonary bypass (CPB) in pediatric cardiac surgery risks lung dysfunction including derecruitment, atelectasis, and inflammation. Continuous positive airway pressure (CPAP) and lung-protective ventilation (LPV) during aortic cross-clamping show inconsistent results in mitigating these risks.

Aims

To investigate whether LPV during aortic cross-clamping under CPB affects postoperative respiratory mechanics and ventilation inhomogeneity compared to apnea or CPAP.

Methods

This prospective, randomized pilot study compared three ventilation strategies during aortic cross-clamping under CPB: apnea, CPAP (5 mbar), and LPV. LPV was standardized using pressure-controlled ventilation at a positive end-expiratory pressure of 5 mbar, ind

SUBMITTER: Billstein C 

PROVIDER: S-EPMC12686771 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature