Arterial human blood flow can be stopped by cables of VWF and platelets without coagulation.

ABSTRACT:

Abstract

Arterial thrombi formed under high shear rates (∼15 000/s) must withstand substantial forces to occlude arteries, as occurs in myocardial infarction or ischemic stroke, driving the need to understand the structural features responsible for their strength. We used scanning electron microscopy and immunofluorescence microscopy to characterize the structure of in vitro high-shear thrombi. We show that the occlusive portion of the thrombus consists of a thick, transverse cable spanning the channel width. The cable is made of hundreds of parallel strings of platelets joined by yarns of von Willebrand factor (VWF) fibers identified by immunofluorescence microscopy. The elements composing the occlusive structure-cable, strings, yarns, and fibers, listed in hierarchical order-are

SUBMITTER: Machenaud ELV 

PROVIDER: S-EPMC12686795 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature