Genetic Background Predicts Uveal Melanoma Patients' Outcomes.

ABSTRACT:

Objective

Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively. The aim of this study was to assess the association between germline genetics and UM outcome and the potential use of a derived prognostic signature for UM.

Design

Cohort study from Institut Curie, Paris (France) and Erasmus University Medical Center, Rotterdam (The Netherlands).

Participants

Patients diagnosed with UM at Institut Curie (N = 2059) and Erasmus University Medical Center (N =576).

Methods

Impact of IRF4 and HERC2 SNPs on survival was assessed in a cohort of 1339 patients with UM by Kaplan-Meier analysis and Cox proportional hazard r

SUBMITTER: Verrier T 

PROVIDER: S-EPMC12686906 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature