Elucidation of the binding interaction interface between AAV serotype 11 capsid protein and host nuclear import proteins.

ABSTRACT: Adeno-associated viruses (AAVs) are widely acknowledged as versatile vectors for gene therapy due to their non-pathogenic nature, inherent capacity for tissue-specific targeting, and their potential for customizable engineering. The N terminus of the AAV capsid protein VP1 plays a pivotal role in guiding AAV capsids into the cell nucleus. However, the precise dynamics of the interaction between the VP1 protein and host nuclear transport proteins, especially across diverse AAV serotypes, remain incompletely understood. AAV11 has emerged as a promising alternative for individuals with elevated antibody titers against AAV2, and in the field of neuroscience, it has demonstrated a strong capability for mapping and manipulating neural circuits, offering the potential for treating neurological an

SUBMITTER: Hoad M 

PROVIDER: S-EPMC12686915 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature