Da-Bu-Yin-Wan and Qian-Zheng-San Alleviate Parkinson's Disease by Activating the Keap1/Nrf2/HO-1 Pathway to Positively Regulate Oxidative Stress.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative disorder that worsens progressively. Different pathological mechanisms are involved in the progression of PD, including the loss of dopaminergic (DA) neurons and exacerbated oxidative damage in the nigrostriatal path. Da-Bu-Yin-Wan combined with Qian-Zheng-San is called Bu-Yin-Qian-Zheng Formula (BYQZF), which is a prescription for PD used in traditional Chinese medicine, but its neuroprotective effects and mechanisms are not well understood.

Purpose

The purpose of this study was to explore how BYQZF can activate the Keap1/Nrf2/HO-1 pathway to effectively lessen oxidative damage, providing insights into its potential anti-PD effects.

Methods

The chemical constituents and pharmacokinetics of BYQZF were analyzed

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12686966 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature