NOD1/RIP2 Pathway Promotes Glioma Progression Through Microglial M2 Polarization.

ABSTRACT:

Background and aim

Glioma is a highly aggressive malignancy of the central nervous system with a poor prognosis. The nucleoside-binding oligomerization domain-containing protein 1 (NOD1)/receptor-interacting protein 2 (RIP2) pathway is involved in various inflammatory responses and is closely associated with microglial polarization. Microglial M2 polarization alters the glioma microenvironment, promoting tumor growth. This study aimed to investigate the role of the NOD1/RIP2 pathway in glioma progression.

Methods

We explored the mechanism of NOD1/RIP2 in glioma progression through bioinformatics analysis, clinical sample evaluation, and in vivo and in vitro experiments. Bioinformatics analysis was conducted to assess NOD1 expression in glioma tissues. Multiparameter MRI and

SUBMITTER: Luan Y 

PROVIDER: S-EPMC12686968 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature