Association of ankle-brachial Index with coronary and extra-coronary calcification in older adults: ARIC study.

ABSTRACT:

Aims

To investigate potentially distinct associations of ankle brachial index (ABI), a marker of subclinical atherosclerosis, with calcification in different vascular beds and cardiac valves.

Methods and results

We studied 1420 ARIC participants (mean age 80.2 [SD 4.1] years, 60.2% female, and 16.6% Blacks). ABI was measured at visit 6 (2016-17) or visit 7 (2018-19), and coronary artery calcification (CAC) and extra-coronary calcification (thoracic aorta, aortic valve, and mitral valve) were assessed through non-contrast cardiac-gated computed tomography. We ran multivariable logistic regression models, with any (Agatston score >0) and high (≥75th percentile) calcification as primary and secondary outcome variables, respectively. For any calcification, ABI ≤0.9 had the stron

SUBMITTER: Bansah EC 

PROVIDER: S-EPMC12686986 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature