Short metallopeptide conjugate nanostructures for selective cadmium capture and detoxification.

ABSTRACT: We report a rationally designed biomimetic supramolecular short metallopeptide conjugate (sMPC) that unites sensitive cadmium detection with active detoxification. These cost-effective and biocompatible assemblies respond to Cd²⁺ by precise metal chelation and stimuli-induced self-assembly, producing a marked fluorescence enhancement for quantification while driving a controlled morphological conversion from cadmium nanoparticles to less toxic nanorods and stabilizing key intermediates. Integrated spectroscopic, microscopic and theoretical analyses reveal the molecular mechanisms of this dynamic organization, advancing fundamental understanding of peptide-metal interactions. Proof-of-concept in vitro (HEK-293) and in vivo-zebrafish-study assays, demonstrate efficie

SUBMITTER: Kautu A 

PROVIDER: S-EPMC12687284 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature