<i>Selaginella</i> extracts extend lifespan and mitigate oxidative stress in <i>Caenorhabditis elegans</i>.

ABSTRACT:

Introduction

Selaginella species hold a traditional place in medicine and cosmetics, but their potential to extend lifespan and the underlying bioactive compounds remain inadequately investigated. This study aims to systematically evaluate the anti-aging properties of diverse Selaginella extracts and to identify the key bioactive components and mechanisms involved.

Methods

We collected 23 Selaginella samples from 13 different provinces across China to assess their geographical influence. Two representative methanol extracts, S4 (high in amentoflavone) and S16 (low in amentoflavone), were selected for in-depth evaluation using the Caenorhabditis elegans model. We employed lifespan assays, stress resistance tests, and comparative transcriptomics to analyze

SUBMITTER: Chen X 

PROVIDER: S-EPMC12687336 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature