Identification of <i>Streptococcus pneumoniae</i><i>-</i>Specific Proteins by Surface-Shaving Proteomics.

ABSTRACT: Streptococcus pneumoniae (pneumococcus) is a prominent cause of bacterial pneumonia, meningitis, and septicemia, causing high morbidity and high mortality, particularly in children and the elderly. In this study, proteomics- and genomics-based approaches were used for the identification of pneumococcal protein and peptide biomarkers of S. pneumoniae for diagnostics and prospective targets for treatment. Through a pan-genome analysis, 11 S. pneumoniae strains, demonstrating genetic variation within the species, were selected for proteomic characterization. Mass spectrometry-based proteomics, in combination with bacterial surface-shaving, were used to study the cell-surface proteome of S. pneumoniae. The data obtained from three biologi

SUBMITTER: Acha Alarcon L 

PROVIDER: S-EPMC12687362 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature