Hydrogen-Mediated Reductive Cross-Coupling of Aryl Iodides with Activated Aryl and Heteroaryl Bromides.

ABSTRACT: Hydrogen-mediated reductive cross-couplings of aryl iodides with activated aryl and heteroaryl bromides are described, along with related homocouplings (Ullmann reactions) and vinylic reductive couplings that occur with cine-substitution. To corroborate key events in the catalytic cycle, Pd-to-Pd transmetalation and cross-selective reductive elimination, dianionic diarylpalladate complexes [Pd(Aryl)(μ-Br)Br]₂[NPr₄]₂ bearing p-fluorophenyl, p-methoxyphenyl and p-nitrophenyl moieties were prepared. Stoichiometric reactions of these complexes in the presence of iodide demonstrate that Pd-to-Pd transmetalation by way of monomeric arylpalladates occurs at a greater rate than reductive elimination and that cross-selective C-C reductive

SUBMITTER: Shen W 

PROVIDER: S-EPMC12687373 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature