An umbrella meta-analysis of microbial therapy on hepatic steatosis, fibrosis, and liver stiffness in metabolic dysfunction-associated steatotic liver disease.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease is considered the leading cause of chronic liver disease worldwide. By now, no confirmed medication is accessible for the treatment of MASLD. Previous studies showed the positive effects of microbial therapy, such as probiotics, prebiotics, and synbiotics. The study aims to summarize the results of a meta-analysis of randomized controlled trials and evaluate the impact of microbial therapy (probiotics, prebiotics, and synbiotics) on liver radioactive indicators in patients with MASLD and hopes to bring certain benefits to the adjuvant treatment of MASLD populations.

Methods

A thorough search of PubMed, Scopus, Web of Science, Embase, and Cochrane Library, from inception up to 4 May 2025, was conducted to fin

SUBMITTER: Kurban G 

PROVIDER: S-EPMC12687379 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature