Glycocalyx kinetics and injury during liver procurement and transplantation as predictors of early graft dysfunction.

ABSTRACT:

Introduction

Ischemia-reperfusion injury causes endothelial damage, partly through degradation of the glycocalyx. This study aimed to evaluate glycocalyx degradation from graft procurement to reperfusion and assess its potential as a biomarker of early graft function (early allograft dysfunction, EAD).

Methods

This single-center observational prospective study was conducted at Paul Brousse Hospital from April 2022 to April 2023. All primary liver transplantation (LT) recipients were included. Glycocalyx degradation was assessed at procurement, at the end of cold ischemia, and during LT in liver graft caval effluent and correlated with liver histological injury. The primary endpoint was EAD, defined as a Model for Early Allograft Function score ≥9. We quantified glycocalyx co

SUBMITTER: Beghdadi N 

PROVIDER: S-EPMC12687380 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature