Anti-IgLON5 Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Anti-IgLON5 disease is now considered a complex and heterogeneous neurological disorder with sleep, movement, and neuroimmunological as well as neurodegenerative aspects. The aim of this systematic review and meta-analysis was to entail the whole clinical spectrum as well as laboratory characteristics, therapeutic interventions and reported outcomes of anti-IgLON5 disease.

Methods

The electronic databases PubMed/MEDLINE, Web of Science and Semantic Scholar were searched for case reports and case series on anti-IgLON5 disease published until July 31, 2024. For inclusion, studies had to report on patients with a positive IgLON5 antibody titer in serum or CSF and be published in English in a peer-reviewed journal. For meta-analyses, only case series with N ≥ 10 patie

SUBMITTER: Grossauer A 

PROVIDER: S-EPMC12687385 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature