SUL-138 mitigates accelerated endothelial aging and protects the kidney.

ABSTRACT: Vascular aging is marked by increased levels of reactive oxygen species in endothelial cells. Reactive oxygen species can, among others, be produced by dysfunctional mitochondria, contributing to acceleration of vascular aging by promoting DNA damage response and senescence. In the aged vasculature, impaired endothelial cell function causes decreased vasodilation, which may also have an impact on peripheral organs such as the kidney. The aim of this study was to investigate the effect of chronic treatment with SUL-138 (30 mg/kg/day), a novel mitochondrial protective compound, on DNA damage-prompted, accelerated endothelial aging and associated kidney dysfunction in mice. Endothelial-specific aging was induced by knock-out (KO) of DNA repair endonuclease Ercc1 in mice [endothelial-cell spec

SUBMITTER: Juttner AA 

PROVIDER: S-EPMC12687458 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature