HO-1 modulates obesity-related renal sodium metabolism via oxidative stress and Na/K-ATPase signaling.

ABSTRACT: The dysregulation of renal sodium metabolism linked to obesity and excessive dietary salt intake is a significant factor in the development of salt-sensitive hypertension. Our previous research has demonstrated that oxidative stress-particularly through the amplification loop of reactive oxygen species (ROS)-plays a critical role in modulating renal sodium handling via Na/K-ATPase signaling. This present study aims to determine whether the antioxidant enzyme heme oxygenase-1 (HO-1) modulates renal sodium metabolism by affecting oxidative stress and the Na/K-ATPase pathway, potentially revealing novel therapeutic avenues. To investigate this, we conducted high-salt dietary interventions and administered Co(III) protoporphyrin IX chloride (CoPP) in both normal and obese C57BL/6J mice. Result

SUBMITTER: Cai J 

PROVIDER: S-EPMC12687461 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature