PRESTA: associating promoter sequences with information on gene expression.

ABSTRACT:

Background

Large sets of well-characterized promoter sequences are required to facilitate the understanding of promoter architecture. The major sequence databases are a prospective source of upstream regulatory regions, but suffer from inaccurate annotation. The software tool PRESTA (PRomoter EST Association) presented in this study is designed for efficient recovery of characterized and partially verified promoters from GenBank and EMBL libraries.

Results

The PRESTA algorithm examines the putative GenBank/EMBL promoters and automatically removes most of the poorly annotated entries. The remaining records are connected to expressed sequence tags (ESTs) through a high-stringency BLAST search. The frequency and source of recovered ESTs provide an estimate of the activity and e

SUBMITTER: Mach V 

PROVIDER: S-EPMC126875 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature