Infant Formula for the Prevention and Treatment of Neonatal Hypoglycaemia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

Neonatal hypoglycaemia is a common metabolic disorder in newborns; if severe or prolonged, it can lead to brain injury. Formula is sometimes used to treat neonatal hypoglycaemia. This study aims to synthesise evidence on the effectiveness of infant formula for the prevention and treatment of neonatal hypoglycaemia.

Methods

Randomised controlled trials (RCTs) and cohort studies comparing infants given formula to those who were not were included. Four databases and four trial registries were searched. Study quality was evaluated using the Cochrane Risk of Bias-1 tool for RCTs and the Newcastle-Ottawa Scale for cohort studies.

Results

We screened titles and abstracts of 6711 records and full texts of 56 records. We included 12 studies: one RCT and 11 cohort studies.

SUBMITTER: Iqbal A 

PROVIDER: S-EPMC12687676 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature