Design and Synthesis of Triazole-Based p-tert-Butylcalix[4]Arene Conjugates and Evaluation of Their Antimicrobial, Antibiofilm, and Anti-Quorum-Sensing Activities.

ABSTRACT: Macrocyclic calix[n]arenes have many applications, with diverse structures that can easily be functionalized either on upper or lower rims, mostly to impart solubility and improve biological activities. In this study, triazole-based p-tert-butylcalix[4]arene conjugates (AT10a and AT10b) and their p-tert-butylphenol analogs (AT10b and AT11b) were synthesized in good yields and characterized using ¹³C NMR and ¹H NMR experiments. The compounds were evaluated for their antimicrobial (AM) activity against Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes), Gram-negative bacteria (Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa), and fungi (Candida albicans, Candida tropicalis), and minimal/minimum inhibitory concentrati

SUBMITTER: Tamfu AN 

PROVIDER: S-EPMC12687697 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature