GDF10 Regulates Iron-Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2.

ABSTRACT:

Background

This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of internal and external experiments.

Methods

The sequence information of CRC patients was obtained from the Cancer Genome Atlas Program (TCGA) database. Key genes were identified through differential expression analysis, enrichment analysis, interaction analysis, and survival curve analysis. Subsequently, Growth and Differentiation Factor 10 (GDF10) overexpression and knockout cell models were developed to investigate the impact of GDF10 on

SUBMITTER: Ouyang K 

PROVIDER: S-EPMC12687720 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature