Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.

ABSTRACT: Adolescent social isolation (aSI) has been demonstrated to increase anxiety-like behavior and ethanol consumption. The ventral pallidum (VP), a basal ganglia structure that receives dopaminergic projections from the VTA, contributes to reward and aversion processing, and is highly responsive to psychosocial stressors. In our study, we sought to characterize the effects of aSI on maladaptive behavioral phenotypes such as anxiety-like behavior, ethanol consumption, and aversion-resistant ethanol-intake as measured by the consumption of ethanol (20 %, v/v) adulterated with the bitterant quinine (0, 3, 10, 30, 100 mg/l). We further used ex vivo fast scan cyclic voltammetry (FSCV) to probe dopamine release kinetics in the VP in response to aSI following both tonic and phasic stimulation.

SUBMITTER: Vaughan GJ 

PROVIDER: S-EPMC12687745 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature