The utility of angiopoietin-2 and blood cell-derived biomarker indices in differentiating rapidly improving acute respiratory distress syndrome (RIARDS) phenotype from persistent-ARDS: a prospective observational study.

ABSTRACT:

Background

Rapidly improving acute respiratory distress syndrome (RIARDS) is defined as normalization of oxygenation (PaO₂/FiO₂ >300 mmHg) within 24 h of invasive mechanical ventilation. Angiopoietin-2 (Ang-2), a marker of endothelial dysfunction, may predict acute respiratory distress syndrome (ARDS) outcomes, but its role in RIARDS is unclear. This study evaluated Ang-2 and other biomarkers for predicting RIARDS and their association with survival.

Research design and methods

In this prospective observational study (June 2023-January 2025) at a 2032-bedded tertiary centre, 193 consecutively enrolled mechanically ventilated ARDS patients were assessed. Demographic, clinical, and laboratory data were recorded on Day 1. Plasma Ang-2 was measured using a

SUBMITTER: Srinivas T 

PROVIDER: S-EPMC12687898 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature